Structure of paecilospirone, a new antibiotic from Paecilomyces.
نویسندگان
چکیده
منابع مشابه
Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.
DNAtopoisomerases I and II are enzymes that alter DNA conformation through a concerted breaking and rejoining of DNAstrands1*. Recently topoisomerase II has been identified as the primary cellular target for a number of clinically important antitumor agents with diverse and unrelated chemical structures2'3*. These antitumor drugs, termed "topoisomerase II poisons" have the commonproperty of sta...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1991
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.55.1187